Neurological complications of coronavirus infection; a comparative review and lessons learned during the COVID-19 pandemic. International Journal of Antimicrobial Agents. Chest radiographs showed patchy shadows in both lungs. Extrapulmonary complications of COVID‐19: A multisystem disease?. The neurology of COVID-19 revisited: A proposal from the Environmental Neurology Specialty Group of the World Federation of Neurology to implement international neurological registries. and you may need to create a new Wiley Online Library account. Use the link below to share a full-text version of this article with your friends and colleagues. Cite this page. This tinctorial change is produced by a variety of alterations and does not represent a specific pattern of accumulation. The progress of 2019 novel coronavirus event in China. Histopathologic Findings of Coronavirus in Lung: A Mini-Review. There was desquamative alveolitis and bronchitis, with proliferation and desquamation of alveolar epithelial cells (CK, EMA positive) (Figure 2), exudation of mononuclear cells, lymphocytes and plasma cells (CD68, LCA positive) (Figure 3), and alveolar oedema. There was prominent splenic atrophy in all three cases, with massive necrosis of lymphoid tissue in white pulp and marginal sinus (Figures 9A and 9B). Arteriolosclerosis is a form of cardiovascular disease involving hardening and loss of elasticity of arterioles or small arteries and is most often associated with hypertension and diabetes mellitus. (B) CD 68 (streptavidin peroxidase, original magnification ×400), (A, B) Formation of hyaline membranes (H&E, original magnification ×200), (A, B) Intracytoplasmic viral inclusion bodies in alveolar epithelial cells (H&E, original magnification ×400). In conclusion, we consider that SARS is a viral disease that can result in injury to multiple organs, although the predominant pathology involves the lungs. European Journal of Clinical Investigation. COVID‐19–associated myositis with severe proximal and bulbar weakness. Hyaline Degeneration. Chronic Diseases and Translational Medicine. In histopathological medical usage, a hyaline substance appears glassy and pink after being stained with haematoxylin and eosin —usually it is an acellular, proteinaceous material. COVID-19: A challenge for forensic and pathological researchers. An example is hyaline cartilage, a transparent, glossy articular joint cartilage. Journal of Clinical and Translational Hepatology. Involvement of the nervous system in COVID-19: The bell should toll in the brain. Oedema was present in the walls of small veins and some veins showed fibrinoid necrosis with infiltration of monocytes, neutrophils, and lymphocytes. Histologically, degenerating myofibers can exhibit a variety of microscopic changes, including cell swelling, hypereosinophilia, vacuolation, loss of striation, fragmentation, and rupture of fibers (Figure 1, Figure 2, Figure 3 (A) Dilatation of SER and clusters of viral particles in smooth endoplasmic reticulin of type 2 alveolar pneumocyte (bar = 500 nm). Overlapping and discrete aspects of the pathology and pathogenesis of the emerging human pathogenic coronaviruses SARS‐CoV, MERS‐CoV, and 2019‐nCoV. Biochemical indicators of coronavirus disease 2019 exacerbation and the clinical implications. Noun. COVID-19 preclinical models: human angiotensin-converting enzyme 2 transgenic mice. Most hyaline degeneration was seen predominantly in the middle layer of the tendon. Description. ( plural hyaline degenerations) (pathology) The degeneration of cellular tissue to form a mass of glassy, homogenous material. Types include hyaline arteriolosclerosis and hyperplastic arteriolosclerosis, both involved with vessel wall thickening and luminal narrowing that may cause downstream ischemic injury. Journal of Advances in Modeling Earth Systems. Potential Roles of the Renin-Angiotensin System in the Pathogenesis and Treatment of COVID-19, Headache, cough, chest pain, progressive dyspnoea, Dense shadowing in right lung and upper part of left lung, Aching pains in whole body, dry cough, progressive dyspnoea, occasional moist rales in both lungs, Red‐coloured haemorrhagic infarct present, Focal haemorrhage in mucosa; turbid fluid in lumen, Bilateral consolidation predominantly in lower lobes, Congestion and focal haemorrhage in mucosa; pale red fluid in lumen, Right pleural adhesions; focal sub‐pleural haemorrhage, Focal haemorrhage; pale red fluid present, Focal haemorrhage and blood‐stained purulent fluid in lumen. Immune responses during COVID-19 infection. The patients may have minor symptoms suggestive of the common cold, such as chills, chest pain, and myalgia. There were focal hyaline degeneration and lysis of cardiac muscle fibres in one case (A1). Thrombosis was present in small veins. Red degeneration (necrobiosis) is a form of degeneration that occurs characteristically but not exclusively in pregnancy, and the process is often the cause of pain and fever. Journal of Stroke and Cerebrovascular Diseases. The pathology is essentially that of diffuse alveolar damage with subsequent progression to acute respiratory distress syndrome. The main pathological changes involve the lungs. Pathological Parameters Vacuolization Dilatation Hyaline Cast Debris Degeneration Pathology damage score 0.231 0.461 0.632 0.331 0.313 P value < 0.0001 < 0.0001 < 0.0001 < 0.0001 < 0.0001 On the other hand, and as indicated in Table 1, the hya- ages the proximal tubules, specifically the S3 segment in line cast and dilatation were more correlated with PDS the outer medulla (1, 5). English Wiktionary. Hyaline definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Extensive consolidation was present in the lungs (Figure 1). Traditional Chinese medicine for the treatment of pulmonary fibrosis. Coronavirus disease 2019 (COVID-19): current status and future perspective. In some patients, the clinical symptoms are inconsistent with the degree of pulmonary involvement, in that while their clinical symptoms appear slight, their lung lesions deteriorate progressively. SARS-CoV-2 detection in different respiratory sites: A systematic review and meta-analysis. The endothelial cells of small pulmonary veins were swollen and shed. Endothelial cells in the systemic venules also desquamated and an inflammatory reaction was present in blood vessel walls (vasculitis). The detailed data are listed in Table 1. Early Insights into Immune Responses during COVID-19. Coronavirus Disease 2019: Coronaviruses and Blood Safety. Pathophysiology of SARS-CoV-2 infection in patients with intracerebral hemorrhage. The families of the deceased gave consent to the autopsies, which were also approved by the medical administration. COVID19 coagulopathy in Caucasian patients. hyaline degeneration ( countable and uncountable, plural hyaline degenerations ) ( pathology) The degeneration of cellular tissue to form a mass of glassy, homogenous material. Neurological Involvement with COVID-19 Review. Bilateral extensive consolidation of the lungs results from a combination of the large number of desquamated and exudated cells and protein exudates that congest the lung tissues, and the extensive formation of hyaline membranes in the alveoli. These lesions are generally not detected grossly, but in some diseases with fibrinoid necrosis of vessels, hemorrhages … All specimens were fixed with 4% neutral formaldehyde, embedded in paraffin wax, and 4 µm sections were cut. We believe that all of these changes most likely result from a complicated process involving (1) disturbed cell metabolism as a result of the release of a large number of viral particles following entry into sensitive cells and rapid replication; (2) intense local vascular reactions; and (3) immune impairment mediated by cellular immunity and cytokine functions 6. SARS is a systemic disease that injures many organs. Genomic variance of the 2019‐nCoV coronavirus. Journal of Forensic Science and Medicine. Definition : The term "hyaline" usually refers to an alteration within cells or in the extracellular space, which gives a homogeneous, glassy, pink appearance in routine histologic sections stained with hematoxylin and eosin. The bullseye sign: A variant of the reverse halo sign in COVID-19 pneumonia. Although it is a variant of CV, the SARS virus has the same virological characteristics as CV. Chondroid metaplasia and calcification may be chronic pathologic changes that … (C) Purple viral inclusion bodies (Macchiavello staining, original magnification ×1000), (A) There is no change in the width of the walls of abnormal alveoli (Ag, original magnification ×200). The most common is hyaline degeneration, which is important in that it should not be mistaken for the coagulative tumor cell necrosis seen in leiomyosarcoma. Our studies show that the hyaline or “amyloid-like” material in the follicles is comprised of two components: the larger hyalinized and fragmented material, presumably of damaged follicular artery in the central portion, surrounded peripherally by exuded plasma proteins, mainly fibrin. A systematic analysis of literature of the department of human neurosciences of sapienza university, italy. Degenerated muscle can grossly appear either pale or dark. Analysis of 92 deceased patients with COVID‐19. SARS-CoV-2 spike protein-mediated cell signaling in lung vascular cells. There was a decrease in bone marrow haematopoietic tissue, with a relative reduction in granulocyte megakaryocyte lineages and localized proliferation of polychromatophilic erythroblasts. • Hyaline degeneration of rectus abdominalis muscle called Zenker’s degeneration, occurring in typhoid fever.Zenker’s degeneration, occurring in typhoid fever. Ultrastructure of cell trafficking pathways and coronavirus: how to recognise the wolf amongst the sheep. There was no evidence of HIV infection, chronic lung disease, diabetes or malignancy in any of the patients. Oxidative Medicine and Cellular Longevity. The onset of the disease in all cases was acute and sudden. Antibodies to coronaviruses are higher in older compared with younger adults and binding antibodies are more sensitive than neutralizing antibodies in identifying coronavirus‐associated illnesses. Adrenal Vascular Changes in COVID-19 Autopsies. How SARS-Cov-2 can involve the central nervous system. Autopsy Services and Emergency Preparedness of a Tertiary Academic Hospital Mortuary for the COVID-19 Public Health Emergency. Elevated Troponin in Patients With Coronavirus Disease 2019: Possible Mechanisms. In order to investigate the clinical pathology of severe acute respiratory syndrome (SARS), the autopsies of three patients who died from SARS in Nan Fang Hospital Guangdong, China were studied retrospectively. In one case (A3), there was apparent dissociation of hepatocyte cords (Figure 10A), together with fatty degeneration and focal necrosis. Lung, liver, kidney, heart, brain, spleen, striated muscle, lymph node, bone marrow, and adrenal gland were collected. COVID-2019 – A comprehensive pathology insight. The rough endoplasmic reticulum (RER) and smooth endoplasmic reticulum (SER) proliferated and dilated greatly. We also found that pulmonary alveolar epithelial cells (mainly type 2) and epithelial cells in bronchi proliferated and desquamated, so that desquamative pulmonary alveolitis and bronchitis occurred. Please check your email for instructions on resetting your password. Promuovere la resilienza della popolazione italiana contro SARS-CoV-2. (B) Patchy necrosis of hepatocytes (H&E, original magnification ×200). In this paper, we report the clinical pathology of three patients who died of SARS in Nan Fang Hospital, Guangzhou, Guangdong, PR China in early 2003. Continua la ricerca nella raccolta di iStock di immagini stock royalty-free con foto di Anatomia umana pronte per essere scaricate in modo semplice e rapido. The vessel walls and circumference of small veins and arteries in the striated muscles in the lower limbs showed oedema and infiltration of monocytes and lymphocytes. Clinicopathologic and Immunohistochemical Findings from Autopsy of Patient with COVID-19, Japan. Fibrinoid necrosis and thrombosis occurred in parts of small veins. There were focal hyaline degeneration and lysis of cardiac muscle fibres in one case (A1). Alveolar macrophage dysfunction and cytokine storm in the pathogenesis of two severe COVID-19 patients. Infectivity of human coronavirus in the brain. The laminar bodies in the cytoplasm of type 2 cells were either markedly reduced in number or absent. The full text of this article hosted at iucr.org is unavailable due to technical difficulties. Contact | Learn about our remote access options, Department of Pathology, Nan Fang Hospital, First Military Medical University, Guangzhou, Guangdong Province, 510515, PR China. Hyaline degeneration, fibrinoid necrosis, and amyloidosis are vascular lesions of small muscular arteries and arterioles and occur in all animal species. The pulmonary lesions mainly involve alveoli and are chiefly composed of desquamative pulmonary alveolitis and bronchitis, for no significant changes in width were observed in most of the alveolar walls or interlobular septa. Hyaline degeneration may occur in fibrous tissue in scars and some tumours due to the deposition of glycoproteins between collagen bundles. This conclusion requires confirmation through additional research. (A) Disappearance of a splenic corpuscle and (B) massive necrosis of lymphatic tissue (H&E, original magnification ×200). All three patients fulfilled the clinical case definition of SARS and the clinical details are listed in Table 1. The first two cases of 2019‐nCoV in Italy: Where they come from?. The typical histopathological features of MPEs have been well described, whereas reports of hyaline changes and low cellular variants are rarely published. It may be seen in patients with cirrhosis of liver who undergo multiple bouts of peritonitis. Desquamation of bronchial epithelial cells was present and there was necrosis of some bronchial walls with infiltration of lymphocytes, monocytes, and neutrophils. Recent studies indicate that the cellular receptors for CV (CD13) exist predominantly in mononuclear cells, venular endothelial cells, epithelial cells in the respiratory tract and renal tubules, fibroblasts, brush‐border cells of the intestine, stromal cells in the bone marrow, and the synaptic membrane of the central nervous system. Systemic toxic changes included degeneration and necrosis of the parenchyma cells in the lung, liver, kidney, heart, and adrenal gland, as well as degeneration of nerve cells in the brain. Pathologic Features of COVID-19: A Concise Review. It is widely used as a descriptive histologic term rather than a … 10.1016/j.jstrokecerebrovasdis.2020.105182. Advanced hyaline degeneration can sometimes include fatty degeneration. The neuroinvasive potential of SARS‐CoV2 may play a role in the respiratory failure of COVID‐19 patients. Hyaline degeneration involves the presence of homogeneous eosinophilic bands or plaques in the extracellular space, which represent the accumulation of proteinaceous tissue 1. RSS 2.0, https://twitter.com/smlungpathguy/status/719648662180274177, https://twitter.com/mariaramir/status/723662298389352452, https://twitter.com/DrSampyRoy/status/733023871725494274, https://twitter.com/DrAlodaini/status/950091320625958913, https://twitter.com/SteveBillingsMD/status/905427241361969152, Collagenous fibrous tissue in old scars may appear hyalinized, but the physiochemical, In long-standing hypertension and diabetes mellitus, the walls of arterioles, especially in the kidney, become hyalinized, owing to extravasated plasma protein and deposition of. Localized necrosis was present and there was apoptosis of lymphocytes in both the spleen and the lymph nodes. review of histologic slides and pathology reports of confluent nodular hyaline areas, geographic hy- from patients already treated. Spleen and lymph nodes There was prominent splenic atrophy in all three cases, with massive necrosis of lymphoid tissue in white pulp and marginal sinus (Figures 9 A and 9 B). Myxoid degeneration was localized extensively in the middle to deep layers of the tendon along with the thin and disoriented collagen fibers. The viral particles and viral inclusion bodies observed by electron microscopy and light microscopy, respectively, in this study are of a similar size and morphological form to those of the SARS virus and our findings therefore support the association of the SARS coronavirus with the pathogenesis of this disease. In the dilated SER, there was exudation of protein with increased electron density. It is often an incidental finding at autopsy. It may also occur in the walls of blood vessels. Also available from Amazon: A Manual Of Pathology. The spleens were soft and their capsules were shrunken. Structure, function, and degeneration of bovine hyaline cartilage: assessment with MR imaging in vitro. The current study presents an unusual case of MPE with marked hyaline degeneration in an elderly male. International Journal of Rheumatic Diseases. Editorial: Nicotine and SARS-CoV-2: COVID-19 may be a disease of the nicotinic cholinergic system. There was hyperplasia of type 1 and type 2 epithelial cells, particularly type 2. (C) Organization of alveolar exudates (A3, duration of 20 days) (Ag, original magnification ×400), (A–C) Mononuclear and multinucleate epithelial giant cells in alveoli (H&E, original magnification ×540), (A) Thrombosis and local necrosis of a vein wall in the lung (H&E, original magnification ×200). Postmortem examination of COVID‐19 patients reveals diffuse alveolar damage with severe capillary congestion and variegated findings in lungs and other organs suggesting vascular dysfunction. There were extensive hyaline membranes in alveoli (Figure 4). The onset of SARS is very acute and sudden. The marginal sinus and germinal centres disappeared in some lymph nodes, and many monocytes and plasmacytoid monocytes could be seen in the remaining lymphatic sinus. It is characterized by several glomerular changes that include diffuse glomerular enlargement by an extracellular eosinophilic deposit accompanied by a reduction in glomerular tuft cellularity ( Figure 1 and Figure 2 ). Mallory bodies in alveolar pneumocytes (chemo-related lung injury), hyaline vessels in PLEOMORPHIC HYALINIZING ANGIECTATIC TUMOR (PHAT), 1996 - 2021 Humpath.com - Human pathology Musculoskeletal Consequences of COVID-19. Home > C. Tissular pathology > hyaline change. Unleashing the mysterious link between COVID-19 and a famous childhood vasculitis: Kawasaki disease. (H&E, original magnification ×400). Mechanisms of SARS-CoV-2 Transmission and Pathogenesis. With your friends and colleagues nuclei, there was extensive bilateral consolidation severe. 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